Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2B | Q14289 | 18/20 | 0.62 |
| ▸ | PTK2 | Q05397 | 16/20 | 0.61 |
| ▸ | AURKA | O14965 | 2/20 | 0.61 |
| ▸ | BRD4 | O60885 | 1/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 3/20 | 0.60 |
| ▸ | CDK1 | P06493 | 2/20 | 0.60 |
| ▸ | CDK7 | P50613 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | STK16 | O75716 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | PAK4 | O96013 | 1/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3147921 | 0.96 | PTK2B (0.65) | PTK2BPTK2AURKABRD4GABRA1 | |
| SCHEMBL3155037 | 0.95 | PTK2B (0.64) | PTK2BPTK2AURKABRD4GABRA1 | |
| SCHEMBL5187241 | 0.94 | PTK2B (0.54) | PTK2BPTK2AURKABRD4GABRA1 | |
| SCHEMBL3151781 | 0.91 | PTK2B (0.69) | PTK2BPTK2AURKABRD4GABRA1 | |
| SCHEMBL5497870 | 0.90 | PTK2B (0.65) | PTK2BPTK2AURKABRD4GABRA1 | |
| SCHEMBL5495120 | 0.89 | PTK2B (0.63) | PTK2BPTK2AURKABRD4GABRA1 | |
| SCHEMBL5498691 | 0.88 | PTK2B (0.70) | PTK2BPTK2AURKABRD4GABRA1 | |
| SCHEMBL5501572 | 0.87 | PTK2B (0.68) | PTK2BPTK2AURKABRD4GABRA1 | |
| SCHEMBL3160071 | 0.86 | PTK2B (0.65) | PTK2BPTK2AURKABRD4GABRA1 | |
| SCHEMBL3147373 | 0.86 | PTK2B (0.71) | PTK2BPTK2AURKABRD4GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625121-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PROD INC (US) | 2010-02-24 | — | — | EP | disclosed |