Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 11/20 | 0.77 |
| ▸ | JAK2 | O60674 | 5/20 | 0.46 |
| ▸ | BRD4 | O60885 | 5/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | CDK4 | P11802 | 3/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | BRD2 | P25440 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21373449 | 1.00 | WEE1 (0.77) | WEE1JAK2BRD4PIK3CDCSF1R | |
| SCHEMBL21373402 | 0.96 | WEE1 (0.75) | WEE1TNK2 | |
| SCHEMBL31557170 | 0.96 | WEE1 (0.75) | WEE1TNK2 | |
| SCHEMBL21373421 | 0.94 | WEE1 (0.79) | WEE1JAK2CSF1RTNK2 | |
| SCHEMBL29859559 | 0.94 | WEE1 (0.79) | WEE1JAK2CSF1RTNK2 | |
| SCHEMBL21373339 | 0.94 | WEE1 (0.72) | WEE1JAK2BRD4TNK2 | |
| SCHEMBL31557243 | 0.94 | WEE1 (0.72) | WEE1JAK2BRD4TNK2 | |
| SCHEMBL31556915 | 0.91 | WEE1 (0.76) | WEE1TNK2 | |
| SCHEMBL21373428 | 0.91 | WEE1 (0.76) | WEE1TNK2 | |
| SCHEMBL21373343 | 0.91 | WEE1 (0.75) | WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025074275-A1 | COMBINATION THERAPIES INCLUDING MYT1 INHIBITORS AND WEE1 INHIBITORS | REPARE THERAPEUTICS, INC. (CA) | 2025-04-10 | — | — | WO | disclosed |