Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 5/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.70 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.70 |
| ▸ | HTR1A | P08908 | 2/20 | 0.70 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.70 |
| ▸ | DRD2 | P14416 | 2/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6554386 | 0.95 | LMNA (0.65) | LMNAMEN1KMT2AHIF1ACYP2D6 | |
| SCHEMBL1138175 | 0.87 | DRD3 (0.59) | LMNAMEN1KMT2AHIF1ACYP2D6 | |
| SCHEMBL1138128 | 0.87 | LMNA (0.70) | LMNAMEN1KMT2AHIF1ACYP2D6 | |
| SCHEMBL3139347 | 0.87 | DRD3 (0.59) | LMNAMEN1KMT2AHIF1ACYP2D6 | |
| SCHEMBL1138126 | 0.87 | LMNA (0.70) | LMNAMEN1KMT2AHIF1ACYP2D6 | |
| SCHEMBL27673539 | 0.85 | LMNA (0.72) | LMNAMEN1KMT2AHIF1ACYP2D6 | |
| SCHEMBL2615158 | 0.84 | LMNA (0.97) | LMNAMEN1KMT2AHIF1ACYP2D6 | |
| SCHEMBL2615163 | 0.84 | LMNA (0.97) | LMNAMEN1KMT2AHIF1ACYP2D6 | |
| SCHEMBL13285188 | 0.84 | LMNA (0.92) | LMNAMEN1KMT2AHIF1ACYP2D6 | |
| Flunarizine SCHEMBL10993579 | 0.84 | LMNA (0.97) | LMNAMEN1KMT2AHIF1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487810-B1 | 4-(DIARYLMETHYL)-1-PIPERAZINYL DERIVATIVES | SUN PHARMA ADVANCED RES CO LTD (IN) | 2010-02-17 | — | — | EP | disclosed |