SCHEMBL31557915

SCHEMBL31557915

COC(=O)c1ccc(C(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)cc1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 2/20 0.44
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA9 Q16790 1/20 0.44
NAMPT P43490 1/20 0.44
ATR Q13535 1/20 0.43
LCK P06239 1/20 0.43
KDM4E B2RXH2 3/20 0.42
MAPT P10636 3/20 0.40
ALDH1A1 P00352 2/20 0.40
PSMB8 P28062 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
MAP4K4 O95819 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
CASP1 P29466 2/20 0.39
GLA P06280 1/20 0.38
GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31557881 0.88 CYP17A1 (0.45) CYP17A1CA12CA1CA9NAMPT
SCHEMBL507957 0.88 CA12 (0.52) CYP17A1CA12CA1CA9NAMPT
SCHEMBL31557897 0.86 NAMPT (0.46) CYP17A1CA12CA1CA9NAMPT
SCHEMBL31557880 0.86 CYP17A1 (0.51) CYP17A1CA12CA1CA9NAMPT
SCHEMBL15898259 0.81 CYP2C9 (0.52) CYP17A1NAMPTKDM4EMAPTALDH1A1
SCHEMBL4315966 0.80 MEN1 (0.59) CYP17A1NAMPTKDM4EMAPTALDH1A1
SCHEMBL2888346 0.80 KDM4E (0.55) CA12CA1CA9KDM4EMAPT
SCHEMBL4984917 0.80 CA12 (0.52) CYP17A1CA12CA1CA9NAMPT
SCHEMBL24891782 0.78 NAMPT (0.55) NAMPTLCKMAPTSMN1; SMN2NPC1
SCHEMBL30182354 0.78 NAMPT (0.55) NAMPTLCKMAPTSMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025102082-A1 CARBOCYCLIC AND HETEROCYCLIC STAT3 INHIBITOR COMPOSITIONS AND METHODS ALTAY THERAPEUTICS, INC. (US) 2025-05-15 WO disclosed