Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | KDM6B | O15054 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176024 | 0.92 | SLC6A7 (0.47) | GBA1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3171321 | 0.92 | GBA1 (0.54) | GBA1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3155347 | 0.92 | GBA1 (0.49) | GBA1LMNAALDH1A1DRD2DRD3 | |
| SCHEMBL3156246 | 0.91 | GBA1 (0.49) | GBA1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3166309 | 0.91 | GBA1 (0.48) | GBA1LMNAALDH1A1MAPTHTT | |
| SCHEMBL3163851 | 0.90 | GBA1 (0.48) | GBA1LMNAALDH1A1DRD2DRD3 | |
| SCHEMBL3172414 | 0.90 | GBA1 (0.50) | GBA1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3163116 | 0.89 | KDM6B (0.50) | GBA1SMN1; SMN2LMNAALDH1A1KDM6B | |
| SCHEMBL3162073 | 0.89 | GBA1 (0.45) | GBA1LMNAALDH1A1DRD2DRD3 | |
| SCHEMBL3175804 | 0.89 | GBA1 (0.51) | GBA1MEN1KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |