Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31564651 | 1.00 | GRM2 (0.47) | GRM2SMN1; SMN2SIRT2SIRT1GAA | |
| SCHEMBL31564555 | 1.00 | GRM2 (0.47) | GRM2SMN1; SMN2SIRT2SIRT1GAA | |
| SCHEMBL31564558 | 0.87 | GRM2 (0.45) | GRM2SMN1; SMN2SIRT2SIRT1GAA | |
| SCHEMBL31564659 | 0.85 | GRM2 (0.45) | GRM2SMN1; SMN2GAAMMP1MMP13 | |
| SCHEMBL31564596 | 0.85 | GRM2 (0.45) | GRM2SMN1; SMN2GAAMMP1MMP13 | |
| SCHEMBL6496941 | 0.81 | GRM2 (0.62) | GRM2SIRT2SIRT1GAAMMP1 | |
| SCHEMBL27154092 | 0.81 | GRM2 (0.62) | GRM2SIRT2SIRT1GAAMMP1 | |
| SCHEMBL6498337 | 0.81 | GRM2 (0.62) | GRM2SIRT2SIRT1GAAMMP1 | |
| SCHEMBL31564655 | 0.79 | MMP1 (0.42) | GRM2SMN1; SMN2SIRT2SIRT1MMP1 | |
| SCHEMBL15399271 | 0.79 | GRM2 (0.53) | GRM2SMN1; SMN2SIRT2SIRT1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025096453-A1 | COMPOUNDS FOR THE TREATMENT OF KIDNEY DISEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-05-08 | — | — | WO | disclosed |