⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8982961 | 0.85 | — | — | |
| SCHEMBL444678 | 0.83 | — | — | |
| SCHEMBL28854323 | 0.81 | — | — | |
| SCHEMBL28235112 | 0.81 | — | — | |
| SCHEMBL20600844 | 0.81 | — | — | |
| SCHEMBL1205334 | 0.75 | KMT2A (0.38) | — | |
| SCHEMBL28075027 | 0.75 | PNMT (0.37) | — | |
| SCHEMBL28059582 | 0.75 | ERN1 (0.50) | — | |
| SCHEMBL4788470 | 0.75 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL3878350 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 423 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230122243-A1 | Heteroaromatic inhibitors of astacin proteinases | VIVORYON THERAPEUTICS N.V. (DE) | 2023-04-20 | — | — | US | claimed |
| CN-114585608-A | Heteroaromatic inhibitors of astacin protease | 维沃永治疗公众有限公司 | 2022-06-03 | — | — | CN | claimed |
| CN-114507175-A | Novel inhibitors of hypnotic proteins alpha and beta | 维沃里翁治疗股份有限公司 | 2022-05-17 | — | — | CN | claimed |
| EP-3986868-A1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | Vivoryon Therapeutics N.V. (DE) | 2022-04-27 | — | — | EP | claimed |
| CN-109195947-B | Novel inhibitors of hypnotic proteins alpha and beta | 维沃里翁治疗股份有限公司 | 2022-03-04 | — | — | CN | claimed |
| EP-3445744-B1 | NOVEL INHIBITORS OF MEPRIN ALPHA AND BETA | VIVORYON THERAPEUTICS AG (DE) | 2021-10-06 | — | — | EP | claimed |
| US-20210198189-A1 | NOVEL INHIBITORS OF MEPRIN ALPHA AND BETA | VIVORYON THERAPEUTICS AG (DE) | 2021-07-01 | — | — | US | claimed |
| US-10975019-B2 | Inhibitors of meprin α and β | VIVORYON THERAPEUTICS AG (DE) | 2021-04-13 | — | — | US | claimed |
| WO-2020249760-A1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | VIVORYON THERAPEUTICS AG (DE) | 2020-12-17 | — | — | WO | claimed |
| EP-3750878-A1 | HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES | Vivoryon Therapeutics AG (DE) | 2020-12-16 | — | — | EP | claimed |
| US-4458069-A | Cephalosporin compounds | CIBA-GEIGY CORPORATION (US) | 1984-07-03 | — | — | US | claimed |
| US-4172199-A | ISOOXACEPHALOSPORINS | BRISTOL-MYERS COMPANY (US) | 1979-10-23 | — | — | US | claimed |
| US-4171439-A | Antibacterial analogs of isocephalosporins | BRISTOL-MYERS COMPANY (US) | 1979-10-16 | — | — | US | claimed |
| US-4171438-A | 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents | BRISTOL-MYERS COMPANY (US) | 1979-10-16 | — | — | US | claimed |
| US-4166906-A | ANTIBIOTICS | BRISTOL-MYERS COMPANY (US) | 1979-09-04 | — | — | US | claimed |
| US-4166905-A | ANTIBIOTICS | BRISTOL-MYERS COMPANY (US) | 1979-09-04 | — | — | US | claimed |
| US-4118566-A | Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents | BRISTOL-MYERS COMPANY (US) | 1978-10-03 | — | — | US | claimed |
| US-4113946-A | Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents | BRISTOL-MYERS COMPANY (US) | 1978-09-12 | — | — | US | claimed |
| US-4112230-A | Δ2,3 -1,4 Morpholine-2-carboxylic acid derivatives as antibacterial agents | BRISTOL-MYERS COMPANY (US) | 1978-09-05 | — | — | US | claimed |
| US-3932465-A | ANTIBIOTIC | CIBA-GEIGY CORPORATION (US) | 1976-01-13 | — | — | US | claimed |