Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.57 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.41 |
| ▸ | TEK | Q02763 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.39 |
| ▸ | TUBB | P07437 | 4/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.39 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177474 | 0.82 | KDR (0.47) | KDREGFRPDGFRBTEKFLT1 | |
| SCHEMBL12409621 | 0.82 | KDR (0.47) | KDREGFRPDGFRBTEKFLT1 | |
| SCHEMBL2179721 | 0.78 | KDR (0.47) | KDREGFRPDGFRBTEKFLT1 | |
| SCHEMBL2179734 | 0.77 | KDR (0.46) | KDREGFRPDGFRBTEKFLT1 | |
| SCHEMBL2179726 | 0.76 | KDR (0.45) | KDREGFRPDGFRBTEKFLT1 | |
| SCHEMBL2180594 | 0.74 | KDR (0.49) | KDREGFRPDGFRBTEKFLT1 | |
| Gw642125X SCHEMBL14013971 | 0.73 | KDR (1.00) | KDREGFRTEKFLT1CDK1 | |
| SCHEMBL2179253 | 0.73 | KDR (0.71) | KDREGFRPDGFRBTEKFLT1 | |
| SCHEMBL2179261 | 0.71 | KDR (0.46) | KDREGFRPDGFRBTEKFLT1 | |
| SCHEMBL2179258 | 0.70 | KDR (0.45) | KDREGFRPDGFRBTEKFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158206-A1 | SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008155016-A1 | SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-12-24 | — | — | WO | disclosed |