Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.47 |
| ▸ | TEK | Q02763 | 4/20 | 0.38 |
| ▸ | FLT1 | P17948 | 3/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 8/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | FER | P16591 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177083 | 0.89 | RIPK1 (0.39) | KDRTEKFLT1CDK1EGFR | |
| SCHEMBL2179734 | 0.83 | KDR (0.46) | KDRTEKFLT1CDK1CHEK1 | |
| SCHEMBL2179261 | 0.83 | KDR (0.46) | KDRTEKFLT1CDK1CHEK1 | |
| SCHEMBL2179726 | 0.82 | KDR (0.45) | KDRTEKFLT1CDK1CHEK1 | |
| SCHEMBL2177474 | 0.79 | KDR (0.47) | KDRTEKFLT1CDK1CHEK1 | |
| SCHEMBL3158751 | 0.78 | KDR (0.57) | KDRTEKFLT1CDK1CHEK1 | |
| SCHEMBL2180594 | 0.73 | KDR (0.49) | KDRTEKFLT1CDK1EGFR | |
| SCHEMBL2179813 | 0.73 | EGFR (0.43) | CHEK1EGFR | |
| SCHEMBL2179775 | 0.73 | RIPK1 (0.39) | KDRTEKFLT1CDK1EGFR | |
| SCHEMBL12409621 | 0.73 | KDR (0.47) | KDRTEKFLT1CDK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166163-A1 | SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166163-A1 | SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF | DPYD, TPMT, TYMP | KDR 1007/4885TEK 374/4885FLT1 475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.