Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 11/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL498384 | 0.89 | NR1H4 (0.44) | NR1H4 | |
| SCHEMBL3155909 | 0.88 | NR1H4 (0.40) | NR1H4TRPM8SCN9A | |
| SCHEMBL3164519 | 0.85 | NR1H4 (0.52) | NR1H4AR | |
| SCHEMBL497775 | 0.84 | NR1H4 (0.41) | NR1H4TRPM8SCN9AMCHR1 | |
| SCHEMBL3159734 | 0.84 | NR1H4 (0.44) | NR1H4TRPM8 | |
| SCHEMBL3168864 | 0.83 | NR1H4 (0.46) | NR1H4 | |
| SCHEMBL3159076 | 0.82 | TRPM8 (0.44) | NR1H4TRPM8SCN9AMCHR1 | |
| SCHEMBL2770610 | 0.82 | TRPM8 (0.38) | NR1H4TRPM8MCHR1 | |
| SCHEMBL27761420 | 0.82 | NR1H4 (0.36) | NR1H4TRPM8SCN9A | |
| SCHEMBL498231 | 0.79 | NR1H4 (0.35) | NR1H4TRPM8SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029558-B1 | COMPOUNDS AND METHODS FOR MODULATING FXR | LILLY CO ELI (US) | 2010-03-10 | — | — | EP | disclosed |
| CN-101448798-A | Compounds and methods for modulating FXR | LILLY CO ELI (US) | 2009-06-03 | — | — | CN | disclosed |