Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3159296 | 1.00 | NR1H4 (0.61) | NR1H4 | |
| SCHEMBL3159467 | 0.90 | NR1H4 (0.63) | NR1H4 | |
| SCHEMBL3159473 | 0.90 | NR1H4 (0.63) | NR1H4 | |
| SCHEMBL2772913 | 0.88 | NR1H4 (0.62) | NR1H4 | |
| SCHEMBL2772915 | 0.88 | NR1H4 (0.62) | NR1H4 | |
| SCHEMBL498384 | 0.83 | NR1H4 (0.44) | NR1H4 | |
| SCHEMBL3149710 | 0.83 | NR1H4 (0.46) | NR1H4 | |
| SCHEMBL10157975 | 0.83 | NR1H4 (0.88) | NR1H4 | |
| SCHEMBL498383 | 0.82 | NR1H4 (0.43) | NR1H4 | |
| SCHEMBL3164111 | 0.81 | NR1H4 (0.79) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029558-B1 | COMPOUNDS AND METHODS FOR MODULATING FXR | LILLY CO ELI (US) | 2010-03-10 | — | — | EP | disclosed |