Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.46 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 8/20 | 0.37 |
| ▸ | PPARA | Q07869 | 4/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27761419 | 0.92 | NR1H4 (0.38) | NR1H4PPARDPPARAPPARGNTRK1 | |
| SCHEMBL3165823 | 0.92 | NR1H4 (0.51) | NR1H4HSD17B13RXRARXRBRXRG | |
| SCHEMBL3158844 | 0.89 | NR1H4 (0.47) | NR1H4RXRARXRBRXRGPPARD | |
| SCHEMBL3159951 | 0.86 | NR1H4 (0.46) | NR1H4HSD17B13RXRARXRBRXRG | |
| SCHEMBL2770877 | 0.86 | NR1H4 (0.42) | NR1H4HSD17B13RXRARXRBRXRG | |
| SCHEMBL3156107 | 0.86 | NR1H4 (0.39) | NR1H4PPARDPPARA | |
| SCHEMBL3150730 | 0.85 | NR1H4 (0.41) | NR1H4PPARDPPARAPPARGFFAR4 | |
| SCHEMBL3159296 | 0.83 | NR1H4 (0.61) | NR1H4 | |
| SCHEMBL3159291 | 0.83 | NR1H4 (0.61) | NR1H4 | |
| SCHEMBL498384 | 0.82 | NR1H4 (0.44) | NR1H4PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029558-B1 | COMPOUNDS AND METHODS FOR MODULATING FXR | LILLY CO ELI (US) | 2010-03-10 | — | — | EP | disclosed |