Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 8/20 | 0.36 |
| ▸ | HRH1 | P35367 | 8/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3329393 | 0.84 | LMNA (0.52) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL3329398 | 0.84 | LMNA (0.52) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| Trifluoroacetic Acid SCHEMBL315987 | 0.83 | LMNA (0.46) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| Trifluoroacetic Acid SCHEMBL3328879 | 0.83 | LMNA (0.46) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL953977 | 0.82 | POLB (0.50) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL953978 | 0.82 | POLB (0.50) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL523122 | 0.82 | POLB (0.55) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL523121 | 0.82 | POLB (0.55) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL3328764 | 0.81 | POLB (0.51) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL3328760 | 0.81 | POLB (0.51) | LMNAPOLBSMN1; SMN2HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081903-B1 | 2-AMINOCARBONYL-PYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2014-05-07 | — | — | EP | disclosed |
| US-8093250-B2 | 2-aminocarbonyl-pyridine derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-01-10 | — | — | US | disclosed |
| US-20100035895-A1 | 2-AMINOCARBONYL-PYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035895-A1 | 2-AMINOCARBONYL-PYRIDINE DERIVATIVES | P2RY12, P2RY2, P2RY1 | LMNA 2766/4885POLB 4323/4885SMN1; SMN2 3232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.