Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.45 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10402322 | 0.79 | HSP90AA1 (0.48) | HSP90AA1CDK5CDK5R1CDK2KDM4E | |
| SCHEMBL2814353 | 0.79 | HSP90AA1 (0.52) | HSP90AA1PRKACACDK5CDK5R1CDK2 | |
| SCHEMBL30595872 | 0.79 | HSP90AA1 (0.52) | HSP90AA1PRKACACDK5CDK5R1CDK2 | |
| SCHEMBL2684649 | 0.77 | HSP90AA1 (0.70) | HSP90AA1AURKAPRKACAADORA2ACDK5 | |
| SCHEMBL3656078 | 0.76 | PRKACA (0.48) | HSP90AA1AURKAPRKACAADORA2ACDK5 | |
| SCHEMBL23071629 | 0.76 | HSP90AA1 (0.63) | HSP90AA1AURKAPRKACAADORA2ACDK5 | |
| SCHEMBL4630886 | 0.75 | HSP90AA1 (0.37) | HSP90AA1ADORA2ACDK5CDK5R1CDK2 | |
| SCHEMBL23453427 | 0.75 | HSP90AA1 (0.46) | HSP90AA1ADORA2AALDH1A1GSK3BLATS1 | |
| SCHEMBL460135 | 0.75 | HSP90AA1 (0.62) | HSP90AA1AURKAPRKACAADORA2ACDK5 | |
| SCHEMBL29462395 | 0.75 | HSP90AA1 (0.62) | HSP90AA1AURKAPRKACAADORA2ACDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093256-B2 | Use of 8-substituted-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives | SANOFI-AVENTIS (FR) | 2012-01-10 | — | — | US | disclosed |
| US-20090281121-A1 | SUBSTITUTED 8-PIPERIDINYL-2-PYRIDINYL-PYRIMIDO[1,2-a] PYRIMIDIN-6-ONE AND 8-PIPERIDINYL-2-PYRIMIDINYL-PYRIMIDO[1,2-a] PYRIMIDIN-6-ONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2009-11-12 | — | — | US | disclosed |
| EP-1921080-B1 | Subsitituted 8-piperidinyl-2-pyridinyl-pyrimido(1,2-a)pyrimidin-6-one and 8-piperidinyl-2-pyrimidinyl-pyrimido(1,2-a)pyrimidin-6-one derivatives | SANOFI AVENTIS (FR) | 2009-08-05 | — | — | EP | disclosed |
| EP-2081938-A2 | SUBSTITUTED 8-PIPERIDINYL-2-PYRIDINYL-PYRIMIDO Ý1,2-A¨PIRIMIDIN-6-ONE AND 8-PIPERIDINYL-2-PYRIMIDI NYL-PYRIMIDOÝ1,2,-A¨PYRIMIDIN-6-ONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008056266-A2 | SUBSTITUTED 8-PIPERIDINYL-2-PYRIDINYL-PYRIMIDO [1,2-A]PYRIMIDIN-6-ONE AND 8-PIPERIDINYL-2-PYRIMIDINYL-PYRIMIDO[1,2-A]PYRIMIDIN-6-ONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-05-15 | — | — | WO | disclosed |
| EP-1921080-A1 | Subsitituted 8-piperidinyl-2-pyridinyl-pyrimido(1,2-a)pyrimidin-6-one and 8-piperidinyl-2-pyrimidinyl-pyrimido(1,2-a)pyrimidin-6-one derivatives | Sanofi-Aventis (FR) | 2008-05-14 | — | — | EP | disclosed |
| US-20080021046-A1 | USE OF 8-SUBSTITUTED-6,7,8,9-TETRAHYDROPYRIMIDO[1,2-a] PYRIMIDIN-4-ONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-01-24 | — | — | US | disclosed |
| US-7247638-B2 | 8-Substituted-6,7,8,9-tetrahydropyrimido [1,2-a] pyrimidin-4-one derivatives. | SANOFI-AVENTIS (FR) | 2007-07-24 | — | — | US | disclosed |
| US-20060035885-A1 | 8-Substituted-6,7,8,9-tetrahydropyrimido [1,2-a] pyrimidin-4-one derivatives | SANOFI-AVENTIS (FR) | 2006-02-16 | — | — | US | disclosed |
| EP-1460075-A1 | Substituted 8-Pyridinyl-6,7,8,9-Tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 8-Phenyl-6-7,8,9-Tetrahydropyrimido[1,2-a]Pyrimidin-4-one derivatives | SANOFI-SYNTHELABO (FR) | 2004-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281121-A1 | SUBSTITUTED 8-PIPERIDINYL-2-PYRIDINYL-PYRIMIDO[1,2-a] PYRIMIDIN-6-ONE AND 8-PIPERIDINYL-2-PYRIMIDINYL-PYRIMIDO[1,2-a] PYRIMIDIN-6-ONE DERIVATIVES | PSEN2, PSEN1, GSK3A | HSP90AA1 2635/4885AURKA 1170/4885PRKACA 875/4885 |
| US-20060035885-A1 | 8-Substituted-6,7,8,9-tetrahydropyrimido [1,2-a] pyrimidin-4-one derivatives | GSK3A, PSEN1, GSK3B | HSP90AA1 3267/4885AURKA 926/4885PRKACA 1580/4885 |
| US-20080021046-A1 | USE OF 8-SUBSTITUTED-6,7,8,9-TETRAHYDROPYRIMIDO[1,2-a] PYRIMIDIN-4-ONE DERIVATIVES | GSK3B, GSK3A, PSEN1 | HSP90AA1 4435/4885AURKA 2245/4885PRKACA 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.