Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3170227 | 0.94 | MEN1 (0.49) | KMT2AMEN1CNR2ALDH1A1CYP2C19 | |
| SCHEMBL3544898 | 0.89 | KMT2A (0.50) | KMT2AMEN1CNR2SMN1; SMN2 | |
| SCHEMBL3169780 | 0.89 | KMT2A (0.50) | KMT2AMEN1CNR2ALDH1A1LMNA | |
| SCHEMBL3160773 | 0.89 | CHRNA7 (0.48) | KMT2AMEN1ALDH1A1CYP2C19POLB | |
| SCHEMBL3174857 | 0.89 | KMT2A (0.54) | KMT2AMEN1CNR2ALDH1A1LMNA | |
| SCHEMBL3541817 | 0.88 | HRH3 (0.53) | KMT2AMEN1CNR2 | |
| SCHEMBL3546171 | 0.88 | KMT2A (0.49) | KMT2AMEN1CNR2ALDH1A1LMNA | |
| SCHEMBL3160554 | 0.87 | KMT2A (0.48) | KMT2AMEN1CNR2ALDH1A1GAA | |
| SCHEMBL3160356 | 0.86 | ALDH1A1 (0.50) | KMT2AMEN1ALDH1A1CYP2C19POLB | |
| SCHEMBL3169524 | 0.76 | KMT2A (0.66) | KMT2AMEN1ALDH1A1CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7648979-B2 | 5-amido-(1H-indol-2-yl)-piperazin-1-yl-methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-01-19 | — | — | US | disclosed |
| US-20080188487-A1 | 5-AMIDO-(1H-INDOL-2-YL)-PIPERAZIN-1-YL-METHANONE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188487-A1 | 5-AMIDO-(1H-INDOL-2-YL)-PIPERAZIN-1-YL-METHANONE DERIVATIVES | HRH4, HRH3, HRH2 | KMT2A 820/4885MEN1 1317/4885CNR2 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.