Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28661472 | 1.00 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL773862 | 1.00 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL28633158 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL32659665 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL28476620 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL25311384 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL22686437 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL29587574 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1291555 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL42945 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116376642-B | Environment-friendly nano insulator cleaning agent and preparation method thereof | 北京中铁科新材料技术有限公司 | 2024-03-22 | — | — | CN | claimed |
| CN-116376642-A | Environment-friendly nano insulator cleaning agent and preparation method thereof | 北京中铁科新材料技术有限公司 | 2023-07-04 | — | — | CN | claimed |
| CN-114686216-A | Double-function nano lubricating additive and preparation method thereof | 南京理工大学 | 2022-07-01 | — | — | CN | claimed |
| CN-114591723-A | Aminated lignin citric acid composite quantum dot As3+Preparation method and application of fluorescent probe | 陕西科技大学 | 2022-06-07 | — | — | CN | claimed |
| CN-111234818-B | Method for synthesizing surface functional group modified carbon quantum dots and application of carbon quantum dots in nano oil displacement | 西南石油大学 | 2022-03-18 | — | — | CN | claimed |
| CN-122010096-A | Carbon dot corrosion inhibitor with excellent corrosion inhibition and tracing performance, preparation method and application | 中国石油大学(华东) | 2026-05-12 | — | — | CN | disclosed |
| US-12453480-B2 | Systems and methods for assessing and treating hemorrhage and other conditions | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2025-10-28 | — | — | US | disclosed |
| US-20250290078-A1 | HMO PRODUCING MICROORGANISM WITH INCREASED ROBUSTNESS TOWARDS GLUCOSE GRADIENTS | DSM IP ASSETS B.V. (NL) | 2025-09-18 | — | — | US | disclosed |
| US-20250108021-A1 | METHOD FOR ENHANCING ENERGY PRODUCTION AND METABOLISM IN CELLS | REPLICON HEALTH OY (FI) | 2025-04-03 | — | — | US | disclosed |
| EP-4514989-A1 | HMO PRODUCING MICROORGANISM WITH INCREASED ROBUSTNESS TOWARDS GLUCOSE GRADIENTS | DSM IP Assets B.V. (NL) | 2025-03-05 | — | — | EP | disclosed |
| CN-119350654-A | Preparation method of carbon dot-based super-strong hydrogel | 西南林业大学 | 2025-01-24 | — | — | CN | disclosed |
| US-12083084-B2 | Method for enhancing energy production and metabolism in cells | REPLICON HEALTH OY (FI) | 2024-09-10 | — | — | US | disclosed |
| CN-105836774-A | A rapid low-energy-consumption preparing method for tricalcium aluminate | 武汉大学 | 2016-08-10 | — | — | CN | disclosed |
| US-20160033533-A1 | 2-HYDROXYGLUTARATE AS A BIOMARKER FOR CHRONIC HYPOXIA | SLOAN KETTERING INST CANCER (US) | 2016-02-04 | — | — | US | disclosed |
| CN-104803471-A | Excellent and efficient carbon fiber biofilm carrier modification method | CHANGZHOU ADVANCED MAT INST OF BEIJING UNIV CHEMIC | 2015-07-29 | — | — | CN | disclosed |
| US-20140314728-A1 | 2-HYDROXYGLUTARATE AS A BIOMARKER FOR CHRONIC HYPOXIA | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-10-23 | — | — | US | disclosed |
| EP-2780700-A1 | 2-HYDROXYGLUTARATE AS A BIOMARKER FOR CHRONIC HYPOXIA | Memorial Sloan Kettering Cancer Center (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075065-A1 | 2-HYDROXYGLUTARATE AS A BIOMARKER FOR CHRONIC HYPOXIA | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2013-05-23 | — | — | WO | disclosed |
| EP-2156205-A1 | SAMPLE PREPARATION METHOD FOR ENHANCEMENT OF NMR SENSITIVITY | Oxford Instruments Molecular Biotools Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008149118-A1 | SAMPLE PREPARATION METHOD FOR ENHANCEMENT OF NMR SENSITIVITY | OXFORD INSTRUMENTS MOLECULAR BIOTOOLS LIMITED (GB) | 2008-12-11 | — | — | WO | disclosed |