Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL29587574 | 1.00 | CA4 (0.94) | CA4ALDH1A1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL1291555 | 1.00 | CA4 (0.94) | CA4ALDH1A1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL22686437 | 1.00 | CA4 (0.94) | CA4ALDH1A1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL227913 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL20668544 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL23012792 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21555662 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL66313 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1231819 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL216857 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 21071 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122076477-A | Fe (Fe)2O3KCl/CaO catalyst, preparation method and application | — | 2026-05-26 | — | — | CN | claimed |
| CN-122076448-A | Sulfur recovery catalyst and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122081457-A | Method for analyzing key gene of thermophilic tetrahymena tolerant methyl mercury | — | 2026-05-26 | — | — | CN | claimed |
| CN-122081075-A | High-permeability cationic surface-active microorganism lysate and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-121377849-B | Passivation culture solution for reducing cadmium in rice and preparation method thereof | Hunan Featured Rice Agriculture Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-117925206-B | Acid-triggered hydrogel plugging agent and preparation method thereof | XI'AN POLYTECHNIC UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-115820316-B | Coal-saving catalyst for thermal power plant and preparation method thereof | NANJING YONGNENG MATERIALS CO.,LTD. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-121379932-B | Culture medium for high-density serum-free suspension culture of BHK-21 cells and application thereof | Zhongsheng tianxinhe (Wuxi) Biotechnology Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122071001-A | Catalyst and method for preparing organic carboxylic acid by catalytic oxidation of aldehyde | 万华化学集团股份有限公司 | 2026-05-22 | — | — | CN | claimed |
| CN-122071676-A | Lactobacillus delbrueckii subspecies bulgaricus with ester aroma and taste of fermented yoghourt and application thereof | 内蒙古伊利实业集团股份有限公司 | 2026-05-22 | — | — | CN | claimed |
| US-4152211-A | Iron containing cell mass glucose isomerase preparation | NOVO INDUSTRI A/S (DK) | 1979-05-01 | — | — | US | claimed |
| US-4100211-A | AND A CHLORINE SOURCE, SOLID SOLUTION CATALYST | THE BF GOODRICH COMPANY (US) | 1978-07-11 | — | — | US | claimed |
| US-4070188-A | One bath type silver dye bleaching and silver bleaching | FUJI PHOTO FILM CO., LTD. (JA) | 1978-01-24 | — | — | US | claimed |
| US-4052190-A | SUSTAINED-RELEASE PLANT FOOD | BURNISHINE PRODUCTS INC. (US) | 1977-10-04 | — | — | US | claimed |
| US-4030976-A | Process for preparing a product having a biological activity | ETABLISSEMENT ANI, CHEZ ME BECK, AVOCAT (FL) | 1977-06-21 | — | — | US | claimed |
| US-4024093-A | Flame retardant polyphenylene ether resin compositions containing a halogenated flame retardant and selected organic iron salts | GENERAL ELECTRIC COMPANY (US) | 1977-05-17 | — | — | US | claimed |
| US-3997348-A | FERRIC SALT BLEACHING SOLUTION | FUJI PHOTO FILM CO., LTD. (JA) | 1976-12-14 | — | — | US | claimed |
| US-RE29015-E | Method of generating precious metal-reducing patterns | WESTERN ELECTRIC COMPANY, INC. (US) | 1976-10-26 | — | — | US | claimed |
| US-3954412-A | Test strip for phenylketone bodies | SHIONOGI & CO., LTD. (JA) | 1976-05-04 | — | — | US | claimed |
| US-3936445-A | FROM ISOXAZOLE, AN O-PHENYLENEDIAMINE AND AN IRON COMPOUND | BADISCHE ANILIN- & SODA-FABRIK AKTIENGESELLSCHAFT (DT) | 1976-02-03 | — | — | US | claimed |