Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL159888 | 0.86 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDSMN1; SMN2PKM | |
| Sulfuric Acid SCHEMBL28557836 | 0.84 | MAPT (0.50) | ALDH1A1KDM4EHPGDSMN1; SMN2PKM | |
| SCHEMBL31169576 | 0.83 | MAPT (0.54) | ALDH1A1KDM4EHPGDSMN1; SMN2PKM | |
| SCHEMBL2030271 | 0.83 | MAPT (0.54) | ALDH1A1KDM4EHPGDSMN1; SMN2PKM | |
| SCHEMBL4613852 | 0.83 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDSMN1; SMN2PKM | |
| SCHEMBL1402286 | 0.82 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDSMN1; SMN2PKM | |
| SCHEMBL316391 | 0.82 | MAPT (0.41) | ALDH1A1KDM4EHPGDSMN1; SMN2PKM | |
| SCHEMBL10868257 | 0.81 | MAPT (0.45) | ALDH1A1KDM4EHPGDSMN1; SMN2PKM | |
| SCHEMBL10659126 | 0.80 | ALDH1A1 (0.65) | ALDH1A1KDM4EHPGDSMN1; SMN2PKM | |
| SCHEMBL611706 | 0.80 | MAPT (0.40) | ALDH1A1KDM4EHPGDSMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 479 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778176-B1 | COMPOSITION FOR COLOURING KERATIN-CONTAINING FIBRES | HENKEL AG & CO KGAA (DE) | 2012-07-25 | — | — | EP | claimed |
| EP-1432388-B1 | AGENT FOR COLOURING FIBRES CONTAINING KERATIN | HENKEL AG & CO KGAA (DE) | 2008-06-18 | — | — | EP | claimed |
| US-7374580-B2 | Dyeing compositions comprising A 1,2-indandione derivative | L'OREAL S.A. (FR) | 2008-05-20 | — | — | US | claimed |
| US-7367993-B2 | Dyeing compositions comprising at least one 1,3-indandione derivative | L'OREAL S.A. (FR) | 2008-05-06 | — | — | US | claimed |
| EP-1502580-B1 | Use in dyeing of aromatic polycyclic vicinal triones with condensed cycles | OREAL (FR) | 2008-01-23 | — | — | EP | claimed |
| EP-1500387-B1 | Use of ninhydrin derivatives for dyeing | OREAL (FR) | 2008-01-09 | — | — | EP | claimed |
| US-7300472-B2 | Agents for coloring fibers containing keratin | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2007-11-27 | — | — | US | claimed |
| EP-1778176-A2 | MEANS FOR COLOURING KERATIN-CONTAINING FIBRES | Henkel Kommanditgesellschaft auf Aktien (DE) | 2007-05-02 | — | — | EP | claimed |
| US-7192455-B2 | Process for dyeing keratin fibers with at least one ninhydrin derivative | L'OREAL S.A. (FR) | 2007-03-20 | — | — | US | claimed |
| US-7182791-B2 | Composition and method of dyeing keratin fibers comprising at least one heteroalkyl group comprising at least one ninhydrin derivative | L'OREAL S.A. (FR) | 2007-02-27 | — | — | US | claimed |
| WO-1998047472-A1 | THE USE OF 1-SUBSTITUTED ISATINS TO DYE FIBERS CONTAINING KERATIN | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1998-10-29 | — | — | WO | claimed |
| WO-1998047473-A1 | USE OF UNSATURATED ALDEHYDES IN DYING FIBERS CONTAINING KERATIN | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1998-10-29 | — | — | WO | claimed |
| EP-0873743-A2 | Use of benzylidene-ketones for dyeing keratinous fibers | Henkel Kommanditgesellschaft auf Aktien (DE) | 1998-10-28 | — | — | EP | claimed |
| EP-0873744-A2 | Use of heterocyclic carbonyl compounds for dying keratinous fibers | Henkel Kommanditgesellschaft auf Aktien (DE) | 1998-10-28 | — | — | EP | claimed |
| EP-0873745-A2 | Dyestuff for keratinous fibers | Henkel Kommanditgesellschaft auf Aktien (DE) | 1998-10-28 | — | — | EP | claimed |
| EP-0873746-A2 | Dyestuff for keratinous fibers | Henkel Kommanditgesellschaft auf Aktien (DE) | 1998-10-28 | — | — | EP | claimed |
| EP-0053851-B1 | NOVEL ANTIFOGGING COMPOUNDS AND THEIR USE IN SILVER HALIDE PHOTOGRAPHY | AGFA-GEVAERT N.V. (BE) | 1985-05-29 | — | — | EP | claimed |
| US-4451555-A | 1-PHENYL-5-MERCAPTOTETRAZOLES | AGFA-GEVAERT, N.V. (BE) | 1984-05-29 | — | — | US | claimed |
| EP-0053851-A1 | Novel antifogging compounds and their use in silver halide photography | AGFA-GEVAERT N.V. (BE) | 1982-06-16 | — | — | EP | claimed |
| US-3943142-A | Dye intermediates and their preparation and use in the synthesis of methine dyes | EASTMAN KODAK COMPANY (US) | 1976-03-09 | — | — | US | claimed |