SCHEMBL31618074

SCHEMBL31618074

Nc1cccc([C@H]2C[C@@H](n3ccc4c(N)ncnc43)[C@H](O)[C@@H]2O)c1

nearest known ligand 0.54

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ AHCY P23526 1/20 0.54
▸ PRMT5 O14744 18/20 0.54
▸ WDR77 Q9BQA1 11/20 0.53
▸ METTL3 Q86U44 1/20 0.52
▸ METTL14 Q9HCE5 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30941668 0.90 AHCY (0.53) AHCYPRMT5WDR77METTL3METTL14
SCHEMBL25047470 0.90 AHCY (0.53) AHCYPRMT5WDR77METTL3METTL14
SCHEMBL31618028 0.89 PRMT5 (0.61) AHCYPRMT5WDR77METTL3METTL14
SCHEMBL25049336 0.89 PRMT5 (0.61) AHCYPRMT5WDR77METTL3METTL14
SCHEMBL25048371 0.89 AHCY (0.68) AHCYPRMT5WDR77METTL3METTL14
SCHEMBL31618075 0.89 AHCY (0.68) AHCYPRMT5WDR77METTL3METTL14
SCHEMBL25048484 0.88 PRMT5 (0.55) AHCYPRMT5WDR77METTL3METTL14
SCHEMBL30940988 0.88 PRMT5 (0.55) AHCYPRMT5WDR77METTL3METTL14
SCHEMBL25046773 0.86 PRMT5 (0.56) AHCYPRMT5WDR77METTL3METTL14
SCHEMBL31618033 0.86 PRMT5 (0.56) AHCYPRMT5WDR77METTL3METTL14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250188110-A1 SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) 2025-06-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250188110-A1 SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION KMT5A, KMT5B, KMT5C AHCY 1576/4885PRMT5 17/4885WDR77 189/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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