Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | DUSP22 | Q9NRW4 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3174310 | 0.89 | ADORA2A (0.43) | KDM4ELMNAALDH1A1HSD17B10ADORA2A | |
| SCHEMBL3170981 | 0.88 | HTT (0.49) | HPGDKDM4EALDH1A1GAAMAPT | |
| SCHEMBL3170604 | 0.86 | ADORA2A (0.40) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL3162093 | 0.86 | ALDH1A1 (0.49) | HPGDKDM4ELMNAALDH1A1HSD17B10 | |
| SCHEMBL3174594 | 0.85 | ADORA2A (0.45) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL3166225 | 0.85 | ADORA2A (0.45) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL3155863 | 0.85 | NPC1 (0.40) | KDM4EALDH1A1GAAMAPTADORA2A | |
| SCHEMBL3162937 | 0.84 | ADORA2A (0.46) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL3169774 | 0.82 | ADORA2A (0.43) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL3161815 | 0.80 | ADORA2A (0.42) | KDM4EALDH1A1MAPTTSHRADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |