Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10610948 | 0.86 | ABL1 (0.49) | PTGS2ABL1GAAMAPTSMN1; SMN2 | |
| SCHEMBL23089679 | 0.85 | PTGS2 (0.51) | PTGS2ABL1GAAMAPTSMN1; SMN2 | |
| SCHEMBL4243790 | 0.85 | PTGS2 (0.48) | PTGS2ABL1GAAMAPTSMN1; SMN2 | |
| SCHEMBL29814629 | 0.85 | PTGS2 (0.51) | PTGS2ABL1GAAMAPTSMN1; SMN2 | |
| SCHEMBL29800289 | 0.85 | PTGS2 (0.48) | PTGS2ABL1GAAMAPTSMN1; SMN2 | |
| SCHEMBL27362505 | 0.84 | ABL1 (0.50) | PTGS2ABL1GAAMAPTSMN1; SMN2 | |
| SCHEMBL27319908 | 0.83 | ABL1 (0.46) | PTGS2ABL1GAAMAPTSMN1; SMN2 | |
| SCHEMBL27434440 | 0.83 | CA12 (0.50) | PTGS2ABL1GAAMAPTSMN1; SMN2 | |
| SCHEMBL597387 | 0.83 | ABL1 (0.46) | PTGS2ABL1GAAMAPTSMN1; SMN2 | |
| SCHEMBL543452 | 0.81 | ABL1 (0.53) | PTGS2ABL1GAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025137158-A1 | DERIVATIVES OF ([1,2,4]TRIAZOLO[5,1-A]ISOQUINOLINE-5-CARBONYL)GLYCINATE AS PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2025-06-26 | — | — | WO | disclosed |