Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10290183 | 0.79 | NOTUM (0.60) | NOTUMFLT3GSK3BKEAP1NFE2L2 | |
| SCHEMBL12352631 | 0.79 | NOTUM (0.60) | NOTUMFLT3GSK3BKEAP1NFE2L2 | |
| SCHEMBL12156463 | 0.78 | P2RX7 (0.67) | NOTUMFLT3GSK3BKEAP1NFE2L2 | |
| SCHEMBL16090354 | 0.77 | P2RX7 (0.55) | NOTUMKEAP1NFE2L2PTGS1PTGS2 | |
| SCHEMBL31636683 | 0.77 | NOTUM (0.57) | NOTUMFLT3GSK3BKEAP1NFE2L2 | |
| SCHEMBL27983551 | 0.77 | NOTUM (0.61) | NOTUMFLT3GSK3BCA9KMT2A | |
| SCHEMBL5484732 | 0.76 | NOTUM (1.00) | NOTUMMAPT | |
| SCHEMBL2583096 | 0.76 | NOTUM (0.56) | NOTUMFLT3GSK3BKEAP1NFE2L2 | |
| SCHEMBL10257033 | 0.76 | NOTUM (0.56) | NOTUMFLT3GSK3BKEAP1NFE2L2 | |
| SCHEMBL616473 | 0.76 | NOTUM (0.60) | NOTUMFLT3GSK3BKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025137158-A1 | DERIVATIVES OF ([1,2,4]TRIAZOLO[5,1-A]ISOQUINOLINE-5-CARBONYL)GLYCINATE AS PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2025-06-26 | — | — | WO | disclosed |