SCHEMBL31638138

SCHEMBL31638138

Cc1cc(-n2nc3c(c2N2CCN(c4ccccc4)C2=O)[C@H](C)N(C(=O)OC(C)(C)C)CC3)cc(C)c1F

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ USP30 Q70CQ3 2/20 0.34
▸ HPGDS O60760 2/20 0.34
▸ GLP1R P43220 8/20 0.34
▸ SCN9A Q15858 3/20 0.34
▸ SCN5A Q14524 1/20 0.33
▸ GPR119 Q8TDV5 1/20 0.33
▸ THRB P10828 2/20 0.33
▸ NR1H2 P55055 1/20 0.32
▸ NR1H3 Q13133 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31050310 0.84 GLP1R (0.34) GLP1RTHRB
SCHEMBL20014821 0.82 NR1H2 (0.33) HPGDSGLP1RTHRBNR1H2NR1H3
SCHEMBL28952435 0.82 NR1H2 (0.33) HPGDSGLP1RTHRBNR1H2NR1H3
SCHEMBL31692240 0.82 THRB (0.33) HPGDSGLP1RTHRBNR1H2NR1H3
SCHEMBL31011024 0.81 GLP1R (0.37) GLP1R
SCHEMBL31424405 0.81 THRB (0.33) USP30HPGDSGLP1RTHRBNR1H2
SCHEMBL31692337 0.81 THRB (0.33) HPGDSGLP1RTHRBNR1H2NR1H3
SCHEMBL25025228 0.80 GLP1R (0.40) GLP1R
SCHEMBL31472076 0.79 GLP1R (0.36) GLP1R
SCHEMBL20014787 0.79 GLP1R (0.36) GLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025137307-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO, INC. (US) 2025-06-26 — — WO disclosed
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