Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 7/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.47 |
| ▸ | FAP | Q12884 | 3/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.47 |
| ▸ | PREP | P48147 | 2/20 | 0.47 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 11/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13668934 | 0.99 | XIAP (0.48) | XIAPDPP4DPP7DPP8FAP | |
| SCHEMBL2767860 | 0.99 | XIAP (0.48) | XIAPDPP4DPP7DPP8FAP | |
| SCHEMBL14985795 | 0.86 | DPP4 (0.49) | XIAPDPP4DPP8DPP9ELANE | |
| SCHEMBL29641757 | 0.86 | XIAP (0.58) | XIAPDPP4DPP7DPP8FAP | |
| SCHEMBL14982872 | 0.86 | ELANE (0.47) | XIAPDPP4DPP7DPP8FAP | |
| SCHEMBL23794392 | 0.85 | DPP4 (0.60) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL10056862 | 0.85 | DPP4 (0.60) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL14865113 | 0.85 | DPP4 (0.60) | DPP4DPP7DPP8FAPDPP9 | |
| Bromide SCHEMBL1509660 | 0.84 | DPP4 (0.49) | XIAPDPP4DPP7DPP8FAP | |
| SCHEMBL14985786 | 0.83 | XIAP (0.46) | XIAPDPP4DPP7DPP8FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608577-B2 | Peptidyl ketones as inhibitors of DPIV | OSI PHARMACEUTICALS, INC. (US) | 2009-10-27 | — | — | US | claimed |
| EP-1543023-B1 | SECONDARY BINDING SITE OF DIPEPTIDYL PEPTIDASE IV (DP IV) | PROSIDION LTD (GB) | 2010-03-17 | — | — | EP | disclosed |