SCHEMBL31648062

SCHEMBL31648062

COc1cc(OC)cc(-c2cc3ccc(NCCCC(F)(F)F)nc3nc2NC(=O)NCCCC(F)(F)F)c1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 20/20 0.49
▸ KDR P35968 18/20 0.49
▸ FGFR2 P21802 17/20 0.49
▸ FGFR4 P22455 17/20 0.49
▸ FGFR3 P22607 17/20 0.49
▸ FLT1 P17948 15/20 0.49
▸ FLT4 P35916 15/20 0.49
▸ GLA P06280 1/20 0.46
▸ SRC P12931 1/20 0.46
▸ CSK P41240 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ ATM Q13315 1/20 0.46
▸ EGFR P00533 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31648385 0.91 FGFR1 (0.61) FGFR1KDRFGFR2FGFR4FGFR3
SCHEMBL31647768 0.88 FGFR1 (0.51) FGFR1KDRFGFR2FGFR4FGFR3
SCHEMBL31647914 0.81 FGFR1 (0.46) FGFR1KDRFGFR2FGFR4FGFR3
SCHEMBL31647687 0.80 FGFR1 (0.62) FGFR1KDRFGFR2FGFR4FGFR3
SCHEMBL31648017 0.78 FGFR1 (0.60) FGFR1KDRFGFR2FGFR4FGFR3
SCHEMBL31648028 0.78 FGFR1 (0.61) FGFR1KDRFGFR2FGFR4FGFR3
SCHEMBL31648474 0.78 FGFR1 (0.48) FGFR1KDRFGFR2FGFR4FGFR3
SCHEMBL31648243 0.76 FGFR1 (0.57) FGFR1KDRFGFR2FGFR4FGFR3
SCHEMBL31648629 0.75 FGFR1 (0.47) FGFR1KDRFGFR2FGFR4FGFR3
SCHEMBL31647899 0.75 FGFR1 (0.45) FGFR1KDRFGFR2FGFR4FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025133660-A1 NOVEL COMPOUNDS FOR HOST DIRECTED ANTIVIRAL STRATEGY SORBONNE UNIVERSITE (FR) 2025-06-26 — — WO disclosed
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