SCHEMBL31648166

SCHEMBL31648166

COc1cc(OC)cc(-c2cc3ccc(Cl)nc3nc2NC(=O)NC(C)(C)C)c1

nearest known ligand 0.67

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 19/20 0.67
▸ FGFR4 P22455 10/20 0.67
▸ FGFR2 P21802 9/20 0.67
▸ FGFR3 P22607 9/20 0.67
▸ EGFR P00533 1/20 0.67
▸ KDR P35968 9/20 0.58
▸ FLT1 P17948 6/20 0.58
▸ FLT4 P35916 6/20 0.58
▸ SRC P12931 3/20 0.57
▸ PDGFRB P09619 2/20 0.57
▸ PDGFRA P16234 2/20 0.57
▸ GLA P06280 1/20 0.54
▸ CSK P41240 1/20 0.54
▸ KMT2A Q03164 1/20 0.54
▸ ATM Q13315 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29366761 0.80 FGFR1 (1.00) FGFR1FGFR4FGFR2FGFR3EGFR
SCHEMBL1248489 0.80 FGFR1 (1.00) FGFR1FGFR4FGFR2FGFR3EGFR
SCHEMBL31647687 0.80 FGFR1 (0.62) FGFR1FGFR4FGFR2FGFR3EGFR
SCHEMBL31648385 0.79 FGFR1 (0.61) FGFR1FGFR4FGFR2FGFR3EGFR
SCHEMBL31648017 0.78 FGFR1 (0.60) FGFR1FGFR4FGFR2FGFR3EGFR
SCHEMBL29390330 0.78 FGFR1 (0.74) FGFR1FGFR4FGFR2FGFR3EGFR
SCHEMBL22532383 0.78 FGFR1 (0.74) FGFR1FGFR4FGFR2FGFR3EGFR
SCHEMBL31648028 0.77 FGFR1 (0.61) FGFR1FGFR4FGFR2FGFR3EGFR
SCHEMBL31648243 0.76 FGFR1 (0.57) FGFR1FGFR4FGFR2FGFR3EGFR
SCHEMBL31648262 0.75 FGFR1 (0.76) FGFR1FGFR4FGFR2FGFR3EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025133660-A1 NOVEL COMPOUNDS FOR HOST DIRECTED ANTIVIRAL STRATEGY SORBONNE UNIVERSITE (FR) 2025-06-26 — — WO disclosed
WO-2025132449-A1 NOVEL COMPOUNDS FOR HOST DIRECTED ANTIVIRAL STRATEGY SORBONNE UNIVERSITE (FR) 2025-06-26 — — WO disclosed
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