Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP46A1 | Q9Y6A2 | 7/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3164415 | 0.93 | ADORA2B (0.39) | ADORA2BADORA2AADORA1ADORA3UTS2R | |
| SCHEMBL3172191 | 0.88 | ADORA2A (0.41) | ADORA2BADORA2AADORA1ADORA3DRD2 | |
| SCHEMBL3162937 | 0.86 | ADORA2A (0.46) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL3162879 | 0.86 | UTS2R (0.44) | ADORA2BADORA2AADORA1ADORA3UTS2R | |
| SCHEMBL3175769 | 0.85 | ADORA2A (0.45) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL3174594 | 0.85 | ADORA2A (0.45) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL3166225 | 0.85 | ADORA2A (0.45) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL3171345 | 0.85 | ADORA2B (0.49) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL3155892 | 0.85 | ADORA2A (0.46) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL3167608 | 0.84 | ADORA2A (0.43) | ADORA2BADORA2AADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |