Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 7/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 7/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | STK25 | O00506 | 2/20 | 0.41 |
| ▸ | RIOK3 | O14730 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | GAK | O14976 | 2/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.41 |
| ▸ | MUSK | O15146 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907965 | 0.99 | PDE4B (0.48) | PDE4BCSF1RCYP2C19KITNAMPT | |
| SCHEMBL25211356 | 0.96 | PDE4B (0.46) | PDE4BCSF1RCYP2C19KITNAMPT | |
| SCHEMBL2907750 | 0.96 | PDE4B (0.48) | PDE4BCSF1RCYP2C19KITNAMPT | |
| SCHEMBL25538690 | 0.95 | PDE4B (0.47) | PDE4BCSF1RCYP2C19KITNAMPT | |
| SCHEMBL25204517 | 0.94 | PDE4B (0.54) | PDE4BCSF1RCYP2C19KITNAMPT | |
| SCHEMBL2916006 | 0.84 | CSF1R (0.56) | CSF1RCYP2C19KITHDAC1HDAC2 | |
| SCHEMBL2908137 | 0.84 | NAMPT (0.44) | PDE4BNAMPTKDM4EMAPTTHRB | |
| SCHEMBL2938527 | 0.83 | DDB1 (0.44) | PDE4BNAMPTKDM4EMAPTTHRB | |
| SCHEMBL3168637 | 0.83 | DDB1 (0.44) | PDE4BNAMPTKDM4EMAPTTHRB | |
| SCHEMBL13096657 | 0.82 | HDAC1 (0.36) | PDE4BCSF1RCYP2C19KITHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645755-B2 | Inhibitors of c-fms kinase | JANSSEN PHARMACEUTICAL N.V. (BE) | 2010-01-12 | — | — | US | disclosed |
| US-7645755-B2 | Inhibitors of c-fms kinase | JANSSEN PHARMACEUTICAL N.V. (BE) | 2010-01-12 | — | — | US | disclosed |
| US-7645755-B2 | Inhibitors of c-fms kinase | JANSSEN PHARMACEUTICAL N.V. (BE) | 2010-01-12 | — | — | US | disclosed |
| US-20060189623-A1 | Inhibitors of c-fms kinase | ILLIG CARL R | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189623-A1 | Inhibitors of c-fms kinase | MUSK, TYK2, FES | PDE4B 4132/4885CSF1R 34/4885CYP2C19 3150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.