SCHEMBL31662220

SCHEMBL31662220

CSc1nc(NCCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)c2c(O)nc(Cl)c(F)c2n1

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.32
FYN P06241 1/20 0.31
SRC P12931 1/20 0.31
ABL1 P00519 1/20 0.31
TP53 P04637 1/20 0.30
THRB P10828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31662079 0.84 LMNA (0.31)
SCHEMBL30743029 0.76
SCHEMBL31527485 0.75
SCHEMBL31521278 0.72
SCHEMBL31662215 0.72
SCHEMBL23884366 0.72 MAPT (0.36)
SCHEMBL31661979 0.70
SCHEMBL31662039 0.70 LMNA (0.31)
SCHEMBL31527257 0.70
SCHEMBL31527275 0.70 SMYD2 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025151594-A1 FUSED AZINES AS RAS INHIBITORS AND METHODS OF USE THEREOF KESTREL THERAPEUTICS INC. (US) 2025-07-17 WO disclosed