SCHEMBL31662407

SCHEMBL31662407

COCOc1cc(-c2nc(OC(C)C)c3c(NCCO[Si](C)(C)C(C)(C)C)nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)c2cc(F)ccc2c1

nearest known ligand 0.43

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KRAS P01116 20/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31662258 0.93 KRAS (0.45) KRAS
SCHEMBL31662187 0.91 KRAS (0.45) KRAS
SCHEMBL31662485 0.85 KRAS (0.47) KRAS
SCHEMBL31662319 0.83 KRAS (0.41) KRAS
SCHEMBL31662037 0.82 KRAS (0.51) KRAS
SCHEMBL31662014 0.82 KRAS (0.42) KRAS
SCHEMBL31662286 0.78 KRAS (0.42) KRAS
SCHEMBL31662097 0.77 KRAS (0.41) KRAS
SCHEMBL31662357 0.77 KRAS (0.43) KRAS
SCHEMBL31662011 0.76 KRAS (0.41) KRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025151594-A1 FUSED AZINES AS RAS INHIBITORS AND METHODS OF USE THEREOF KESTREL THERAPEUTICS INC. (US) 2025-07-17 WO disclosed