SCHEMBL31663080

SCHEMBL31663080

COc1[nH]nc(C)c1C(=O)Cl

nearest known ligand 0.42

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 1/20 0.42
GAA P10253 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29409964 0.82 PDE4D (0.43) PDE4DSMN1; SMN2
SCHEMBL23926008 0.75 PDE4D (0.57) PDE4DGAA
SCHEMBL10720445 0.69 PDE4D (0.46) PDE4DGAA
SCHEMBL22864195 0.69
SCHEMBL14193495 0.68
SCHEMBL4754626 0.65 PDE4D (0.66) PDE4DGAASMN1; SMN2
SCHEMBL11209524 0.65 HCAR2 (0.44) PDE4DSMN1; SMN2
SCHEMBL19120417 0.64
SCHEMBL10719424 0.63 PDE4D (0.71) PDE4DGAASMN1; SMN2
SCHEMBL11205284 0.63 PDE4D (0.47) PDE4DGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025149628-A1 PIPERIDINE DERIVATIVES AS INHIBITORS OF NICOTINAMIDE N-METHYL TRANSFERASE ASTRAZENECA AB (SE) 2025-07-17 WO disclosed