Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640767 | 0.79 | PDE4D (0.59) | PDE4DDYRK1AHCAR2LMNAL3MBTL1 | |
| SCHEMBL1663754 | 0.79 | PDE4D (0.59) | PDE4DDYRK1AHCAR2LMNAL3MBTL1 | |
| SCHEMBL15777023 | 0.77 | PDE4D (0.57) | PDE4DDYRK1AHCAR2LMNAL3MBTL1 | |
| SCHEMBL10839267 | 0.77 | PDE4D (0.56) | PDE4DDYRK1AHCAR2LMNAL3MBTL1 | |
| SCHEMBL4754626 | 0.76 | PDE4D (0.66) | PDE4DDYRK1ALMNAL3MBTL1GAA | |
| SCHEMBL31663080 | 0.75 | PDE4D (0.42) | PDE4DGAA | |
| SCHEMBL8006591 | 0.74 | PDE4D (0.53) | PDE4DDYRK1AHCAR2LMNAL3MBTL1 | |
| SCHEMBL10858885 | 0.74 | PDE4D (0.63) | PDE4DDYRK1AHCAR2LMNAL3MBTL1 | |
| SCHEMBL352117 | 0.74 | PDE4D (0.53) | PDE4DDYRK1AHCAR2LMNAL3MBTL1 | |
| SCHEMBL5317321 | 0.74 | PDE4D (0.37) | PDE4DHCAR2GAAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021211922-A1 | SPIRO-SULFONIMIDAMIDE DERIVATIVES AS INHIBITORS OF MYELOID CELL LEUKEMIA-1 (MCL-1) PROTEIN | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2021-10-21 | — | — | WO | disclosed |