Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 6/20 | 0.67 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 5/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16117831 | 1.00 | KRAS (0.67) | KRASSHMT2GAAEGFRERBB2 | |
| SCHEMBL21302149 | 0.92 | KRAS (0.80) | KRASSHMT2GAAEGFRERBB2 | |
| SCHEMBL17833941 | 0.92 | KRAS (0.56) | KRASSHMT2GAAEGFRERBB2 | |
| SCHEMBL16122631 | 0.90 | KRAS (0.76) | KRASSHMT2GAAEGFRERBB2 | |
| SCHEMBL16122360 | 0.90 | KRAS (0.57) | KRASGAAEGFRERBB2KMT2A | |
| SCHEMBL31672385 | 0.89 | KRAS (0.84) | KRASSHMT2GAA | |
| SCHEMBL16117848 | 0.89 | KRAS (0.84) | KRASSHMT2GAA | |
| SCHEMBL16122814 | 0.88 | KRAS (0.50) | KRASGAAEGFRERBB2KMT2A | |
| SCHEMBL22550951 | 0.87 | KRAS (0.66) | KRASSHMT2GAAKMT2AKDM4E | |
| SCHEMBL16122893 | 0.87 | KRAS (0.65) | KRASSHMT2GAAEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE50527-E1 | Covalent inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2025-08-12 | — | — | US | disclosed |