Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 15/20 | 0.84 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16117848 | 1.00 | KRAS (0.84) | KRASOPRK1SHMT2HRH3GAA | |
| SCHEMBL16117849 | 0.92 | KRAS (0.79) | KRAS | |
| SCHEMBL31672348 | 0.92 | KRAS (0.79) | KRAS | |
| SCHEMBL16103039 | 0.91 | KRAS (1.00) | KRASOPRK1 | |
| SCHEMBL31672334 | 0.91 | KRAS (1.00) | KRASOPRK1 | |
| SCHEMBL16117852 | 0.90 | KRAS (0.79) | KRASOPRK1SHMT2GAA | |
| SCHEMBL16122845 | 0.89 | KRAS (0.77) | KRASOPRK1SHMT2HRH3GAA | |
| SCHEMBL20515169 | 0.89 | KRAS (0.77) | KRASOPRK1SHMT2 | |
| SCHEMBL16117831 | 0.89 | KRAS (0.67) | KRASSHMT2GAA | |
| SCHEMBL16117836 | 0.89 | KRAS (0.67) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE50527-E1 | Covalent inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2025-08-12 | — | — | US | disclosed |