Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of L-Citrulline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.45 |
| ▸ | GSR | P00390 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Citrulline SCHEMBL319675 | 1.00 | OTC (0.48) | OTCSMN1; SMN2DDAH1GSRNOS2 | |
| L-Citrulline SCHEMBL319676 | 1.00 | OTC (0.48) | OTCSMN1; SMN2DDAH1GSRNOS2 | |
| L-Citrulline SCHEMBL13276387 | 0.98 | OTC (0.47) | OTCSMN1; SMN2DDAH1GSRNOS2 | |
| L-Citrulline SCHEMBL9056462 | 0.89 | OTC (0.51) | OTCDDAH1GSRNOS2CYP1A2 | |
| L-Citrulline SCHEMBL9056465 | 0.89 | OTC (0.51) | OTCDDAH1GSRNOS2CYP1A2 | |
| Arginine SCHEMBL30193366 | 0.88 | OTC (0.46) | OTCSMN1; SMN2DDAH1GSRNOS2 | |
| Arginine SCHEMBL423591 | 0.88 | OTC (0.46) | OTCSMN1; SMN2DDAH1GSRNOS2 | |
| Arginine SCHEMBL21827041 | 0.88 | OTC (0.46) | OTCSMN1; SMN2DDAH1GSRNOS2 | |
| Arginine SCHEMBL423592 | 0.88 | OTC (0.46) | OTCSMN1; SMN2DDAH1GSRNOS2 | |
| L-Citrulline SCHEMBL215403 | 0.87 | OTC (0.59) | OTCDDAH1GSRNOS2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3629772-B1 | USE OF CITRULLINE AND GLUTATHIONE TO INCREASE MUSCLE MASS | KYOWA HAKKO BIO CO LTD (JP) | 2025-08-13 | — | — | EP | disclosed |