Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of L-Citrulline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.51 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.48 |
| ▸ | GSR | P00390 | 2/20 | 0.44 |
| ▸ | NOS2 | P35228 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | GRM8 | O00222 | 1/20 | 0.42 |
| ▸ | GRM6 | O15303 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Citrulline SCHEMBL9056462 | 1.00 | OTC (0.51) | OTCDDAH1GSRNOS2CYP1A2 | |
| L-Citrulline SCHEMBL15909604 | 0.91 | OTC (0.59) | OTCDDAH1GSRNOS2CYP1A2 | |
| L-Citrulline SCHEMBL20587 | 0.91 | OTC (0.59) | OTCDDAH1GSRNOS2CYP1A2 | |
| L-Citrulline SCHEMBL15909605 | 0.91 | OTC (0.59) | OTCDDAH1GSRNOS2CYP1A2 | |
| L-Citrulline SCHEMBL215403 | 0.91 | OTC (0.59) | OTCDDAH1GSRNOS2CYP1A2 | |
| L-Citrulline SCHEMBL9070200 | 0.91 | OTC (0.59) | OTCDDAH1GSRNOS2CYP1A2 | |
| L-Citrulline SCHEMBL437142 | 0.91 | OTC (0.59) | OTCDDAH1GSRNOS2CYP1A2 | |
| L-Citrulline SCHEMBL4542892 | 0.91 | OTC (0.59) | OTCDDAH1GSRNOS2CYP1A2 | |
| L-Citrulline SCHEMBL22426116 | 0.91 | OTC (0.59) | OTCDDAH1GSRNOS2CYP1A2 | |
| L-Citrulline SCHEMBL288641 | 0.91 | OTC (0.59) | OTCDDAH1GSRNOS2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240285567-A1 | COMPOSITIONS AND METHODS FOR IMPROVING KIDNEY FUNCTION | CROSS III WILLIAM H (US) | 2024-08-29 | — | — | US | claimed |
| US-20240285567-A1 | COMPOSITIONS AND METHODS FOR IMPROVING KIDNEY FUNCTION | CROSS III WILLIAM H (US) | 2024-08-29 | — | — | US | disclosed |
| EP-2531224-A2 | COMPOSITIONS AND METHODS RELATING TO ARGININOSUCCINATE SYNTHETASE | Banyan Biomarkers, Inc. (US) | 2012-12-12 | — | — | EP | disclosed |
| WO-2012141674-A2 | COMPOSITIONS AND METHODS RELATING TO ARGININOSUCCINATE SYNTHETASE | BANYAN BIOMARKERS, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
| WO-1996003158-A1 | USE OF LOW MOLECULAR WEIGHT AMINO ACIDS IN OPHTHALMIC COMPOSITIONS | ALCON LABORATORIES, INC. (US) | 1996-02-08 | — | — | WO | disclosed |