Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | FYN | P06241 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 6/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.32 |
| ▸ | CDK2 | P24941 | 6/20 | 0.32 |
| ▸ | TTK | P33981 | 6/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31677033 | 0.81 | TSHR (0.36) | TSHRTDP1ALDH1A1SIRT5XDH | |
| SCHEMBL20074201 | 0.77 | CDC7 (0.40) | TDP1ACVR1ALDH1A1CDK2MAPKAPK5 | |
| SCHEMBL20074294 | 0.76 | KDM5B (0.40) | TSHRACVR1AURKACCNA2CDK2 | |
| SCHEMBL20074198 | 0.76 | KDM5B (0.44) | TSHRAURKAKDM5BFGFR3AURKB | |
| SCHEMBL20074296 | 0.75 | CHEK1 (0.42) | TSHRACVR1ALDH1A1AURKAKDM5B | |
| SCHEMBL31677015 | 0.75 | SMN1; SMN2 (0.45) | ALDH1A1 | |
| SCHEMBL31676986 | 0.71 | CDK8 (0.45) | FYNACVR1CDK2KDM5BAURKB | |
| SCHEMBL31677026 | 0.71 | KDM5B (0.40) | TSHRKDM5BFGFR3AURKB | |
| SCHEMBL31677002 | 0.70 | POLB (0.34) | TSHRTDP1CCNA2CDK2TTK | |
| SCHEMBL20074119 | 0.69 | KDM5B (0.46) | TSHRALDH1A1SIRT5KDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3525785-B1 | KDM5 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-08-27 | — | — | EP | claimed |