Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 13/20 | 0.40 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20074288 | 0.86 | KDM4E (0.50) | CDK1MAPK1GSK3AGSK3BCDK5 | |
| SCHEMBL20074296 | 0.84 | CHEK1 (0.42) | CDK9DAPK3CDK1PRKACACSNK1A1 | |
| SCHEMBL31677033 | 0.83 | TSHR (0.36) | MAPKAPK2KDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL31677015 | 0.83 | SMN1; SMN2 (0.45) | PKN2MAPKAPK2ALDH1A1SMN1; SMN2KIT | |
| SCHEMBL15659549 | 0.80 | ALDH1A1 (0.51) | CDK1GSK3AGSK3BCDK5KDM4E | |
| SCHEMBL20074293 | 0.77 | EGLN2 (0.48) | MAPK1MAPKAPK2KDM4EALDH1A1LMNA | |
| SCHEMBL20074290 | 0.77 | EGLN2 (0.48) | CDK9DAPK3PRKACACSNK1A1MAPKAPK2 | |
| SCHEMBL31676996 | 0.77 | TSHR (0.34) | CHEK2CDK2AKT1ACVR1MAPKAPK5 | |
| SCHEMBL20074294 | 0.75 | KDM5B (0.40) | CDK2MAPK1ACVR1KIT | |
| SCHEMBL31677038 | 0.73 | KDM5B (0.42) | KDM4EALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975084-B2 | KDM5 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-04-13 | — | — | US | disclosed |
| WO-2018071283-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975084-B2 | KDM5 inhibitors | KDM5A, KDM5B, KDM5C | CDC7 623/4885PKN1 790/4885PKN2 1103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.