SCHEMBL31679068

SCHEMBL31679068

O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC(F)(c2ccccn2)CC1

nearest known ligand 0.69

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ TRPV1 Q8NER1 14/20 0.69
▸ EPHX2 P34913 1/20 0.56
▸ TRPM8 Q7Z2W7 2/20 0.54
▸ NAMPT P43490 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2723508 1.00 TRPV1 (0.69) TRPV1EPHX2TRPM8NAMPT
SCHEMBL2731876 0.91 TRPV1 (0.59) TRPV1EPHX2TRPM8NAMPT
SCHEMBL2723735 0.87 TRPV1 (0.73) TRPV1EPHX2TRPM8NAMPT
SCHEMBL2731250 0.86 TRPV1 (0.61) TRPV1EPHX2TRPM8NAMPT
SCHEMBL2723838 0.85 TRPV1 (0.60) TRPV1EPHX2TRPM8NAMPT
SCHEMBL2725132 0.84 TRPV1 (0.50) TRPV1EPHX2NAMPT
SCHEMBL31679071 0.84 TRPV1 (0.50) TRPV1EPHX2NAMPT
SCHEMBL2723365 0.83 SLC6A7 (0.56) TRPV1EPHX2NAMPT
SCHEMBL2723660 0.83 TRPV1 (0.79) TRPV1TRPM8
SCHEMBL2727164 0.83 TRPV1 (0.79) TRPV1EPHX2TRPM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12403139-B2 Methods and compositions for prevention and treatment of cardiac hypertrophy UNIVERSITY OF HAWAII (US) 2025-09-02 — — US claimed
Send feedback