Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ACACB | O00763 | 3/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389092 | 0.90 | GPR119 (0.63) | GPR119CYP2C9 | |
| SCHEMBL3165831 | 0.88 | GPR119 (0.53) | GPR119CYP2C9ACACB | |
| SCHEMBL3160967 | 0.86 | GPR119 (0.54) | GPR119CYP2C9 | |
| SCHEMBL3161673 | 0.82 | GPR119 (0.62) | GPR119CYP2C9 | |
| SCHEMBL3162157 | 0.82 | GPR119 (0.61) | GPR119CYP2C9 | |
| SCHEMBL3164419 | 0.80 | GPR119 (0.60) | GPR119CYP2C9 | |
| SCHEMBL3160437 | 0.80 | GPR119 (0.56) | GPR119CYP2C9ACACB | |
| SCHEMBL3160860 | 0.80 | GPR119 (0.59) | GPR119CYP2C9 | |
| SCHEMBL3169459 | 0.79 | GPR119 (0.55) | GPR119CYP2C9ACACB | |
| SCHEMBL3163993 | 0.79 | GPR119 (0.57) | GPR119CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644357-B9 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2010-03-24 | — | — | EP | claimed |
| EP-1644357-B1 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2007-12-12 | — | — | EP | claimed |