Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | ACACB | O00763 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389117 | 0.90 | GPR119 (0.66) | GPR119CYP2C9 | |
| SCHEMBL3165831 | 0.88 | GPR119 (0.53) | GPR119CYP2C9ACACB | |
| SCHEMBL3164182 | 0.86 | GPR119 (0.58) | GPR119CYP2C9ACACB | |
| SCHEMBL3165438 | 0.86 | GPR119 (0.58) | GPR119CYP2C9ACACB | |
| SCHEMBL3167060 | 0.86 | GPR119 (0.58) | GPR119CYP2C9 | |
| SCHEMBL6362661 | 0.86 | GPR119 (0.52) | GPR119CYP2C9 | |
| SCHEMBL3167356 | 0.86 | GPR119 (0.57) | GPR119CYP2C9 | |
| SCHEMBL3161999 | 0.86 | GPR119 (0.57) | GPR119CYP2C9ACACB | |
| SCHEMBL3169106 | 0.84 | GPR119 (0.56) | GPR119CYP2C9 | |
| SCHEMBL3164119 | 0.84 | GPR119 (0.61) | GPR119CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644357-B9 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2010-03-24 | — | — | EP | claimed |
| EP-1644357-B1 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2007-12-12 | — | — | EP | claimed |