Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3164007 | 0.90 | GPR119 (0.79) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3165866 | 0.89 | GPR119 (0.68) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3164569 | 0.89 | GPR119 (0.65) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389172 | 0.89 | GPR119 (0.80) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3155095 | 0.88 | GPR119 (0.64) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3155204 | 0.87 | GPR119 (0.63) | GPR119CYP2C9KCNH2 | |
| SCHEMBL4718453 | 0.85 | GPR119 (0.79) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3164563 | 0.84 | GPR119 (0.70) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3174959 | 0.82 | GPR119 (0.68) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3165746 | 0.82 | GPR119 (0.55) | GPR119CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644357-B9 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2010-03-24 | — | — | EP | claimed |
| EP-1644357-B1 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2007-12-12 | — | — | EP | claimed |