SCHEMBL31691386

SCHEMBL31691386

COc1ccc(C(C)(C)C)cc1S(=O)(=O)NC(=O)c1ccc(Cn2cccn2)c(I)c1

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ ALPL P05186 1/20 0.41
▸ KAT7 O95251 15/20 0.41
▸ KAT6A Q92794 15/20 0.41
▸ KAT6B Q8WYB5 10/20 0.41
▸ LMNA P02545 1/20 0.40
▸ HDAC1 Q13547 1/20 0.39
▸ HDAC6 Q9UBN7 1/20 0.39
▸ KAT5 Q92993 7/20 0.39
▸ KAT8 Q9H7Z6 7/20 0.39
▸ KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31691246 0.92 ALPL (0.43) ALPLKAT7KAT6AKAT6BLMNA
SCHEMBL31691394 0.91 KAT7 (0.44) ALPLKAT7KAT6AKAT6BLMNA
SCHEMBL31516641 0.91 KAT7 (0.46) ALPLKAT7KAT6AKAT6BLMNA
SCHEMBL31516707 0.90 KAT7 (0.48) ALPLKAT7KAT6AKAT6BLMNA
SCHEMBL31516663 0.90 KAT7 (0.45) ALPLKAT7KAT6AKAT6BLMNA
SCHEMBL31516723 0.89 KAT7 (0.44) ALPLKAT7KAT6AKAT6BLMNA
SCHEMBL31691431 0.89 KAT7 (0.45) ALPLKAT7KAT6AKAT6BLMNA
SCHEMBL31691347 0.88 KAT7 (0.40) ALPLKAT7KAT6AKAT6BLMNA
SCHEMBL31172569 0.88 KAT7 (0.42) ALPLKAT7KAT6AKAT6BLMNA
SCHEMBL31525826 0.88 HDAC1 (0.54) ALPLKAT7KAT6AKAT6BLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304535-A1 KAT6 Inhibitors BEIGENE SWITZERLAND GMBH (CH) 2025-10-02 — — US disclosed
WO-2025201504-A1 KAT6 INHIBITORS BEIGENE (SUZHOU) CO., LTD. (CN) 2025-10-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304535-A1 KAT6 Inhibitors KAT6A, KAT6B, KAT2A ALPL 4303/4885KAT7 4/4885KAT6A 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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