Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 10/20 | 0.38 |
| ▸ | HTR2A | P28223 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 11/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735200 | 0.89 | HTR2A (0.51) | HTR2AHTR2CDRD2OPRL1OPRM1 | |
| SCHEMBL734919 | 0.88 | HTR2A (0.52) | HTR2AHTR2CDRD2OPRL1OPRM1 | |
| SCHEMBL735036 | 0.83 | OPRL1 (0.45) | HTR2AHTR2CDRD2OPRL1OPRM1 | |
| SCHEMBL736297 | 0.81 | OPRL1 (0.48) | HTR2AHTR2CDRD2OPRL1OPRM1 | |
| Citric Acid SCHEMBL3165180 | 0.80 | HTR2A (0.45) | HTR2AHTR2CDRD2OPRL1OPRM1 | |
| SCHEMBL734752 | 0.80 | KDM4E (0.47) | OPRL1OPRM1OGFRL1 | |
| SCHEMBL735958 | 0.79 | OPRM1 (0.43) | HTR2AHTR2COPRL1OPRM1OGFRL1 | |
| Hydrochloric Acid SCHEMBL735008 | 0.79 | KDM4E (0.46) | OPRL1OPRM1OGFRL1 | |
| SCHEMBL734911 | 0.79 | OPRM1 (0.51) | HTR2AHTR2CDRD2OPRL1OPRM1 | |
| SCHEMBL735121 | 0.78 | OPRM1 (0.50) | HTR2AHTR2CDRD2OPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | OPRM1 1029/4885HTR2A 238/4885HTR2C 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.