Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR known ✓ | Q92847 | 1/20 | 0.45 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.94 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.51 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 4/20 | 0.47 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.45 |
| ▸ | ITGAL | P20701 | 2/20 | 0.45 |
| ▸ | CPB1 | P15086 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL29360257 | 0.99 | SLC15A2 (0.92) | SLC15A2CPB2SLC6A5RENITGB2 | |
| SCHEMBL30175135 | 0.97 | SLC15A2 (1.00) | SLC15A2CPB2SLC6A5RENITGB2 | |
| SCHEMBL22462015 | 0.97 | SLC15A2 (1.00) | SLC15A2CPB2SLC6A5RENITGB2 | |
| SCHEMBL19087235 | 0.97 | SLC15A2 (1.00) | SLC15A2CPB2SLC6A5RENITGB2 | |
| SCHEMBL25354642 | 0.96 | SLC15A2 (0.98) | SLC15A2CPB2SLC6A5RENITGB2 | |
| SCHEMBL28851961 | 0.96 | SLC15A2 (0.98) | SLC15A2CPB2SLC6A5RENITGB2 | |
| SCHEMBL29349986 | 0.94 | SLC15A2 (0.94) | SLC15A2CPB2SLC6A5RENITGB2 | |
| SCHEMBL29352785 | 0.93 | SLC15A2 (0.92) | SLC15A2CPB2SLC6A5RENITGB2 | |
| SCHEMBL29351224 | 0.93 | SLC15A2 (0.92) | SLC15A2CPB2SLC6A5RENITGB2 | |
| SCHEMBL22217022 | 0.88 | SLC15A2 (0.79) | SLC15A2CPB2SLC6A5RENITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250313552-A1 | NICOTINATE ESTERS AND THERAPEUTIC METHODS OF USE THEREOF | NEW FRONTIER BIO INC (US) | 2025-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250313552-A1 | NICOTINATE ESTERS AND THERAPEUTIC METHODS OF USE THEREOF | NNT, NNMT, NAMPT | GHSR 2218/4885SLC15A2 1132/4885CPB2 2332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.