Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LARS1 | Q9P2J5 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22208563 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2HPGDMEN1KMT2ANPSR1 | |
| SCHEMBL24328780 | 0.81 | MAPT (0.42) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL9386246 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDMEN1KMT2ANPSR1 | |
| SCHEMBL27253937 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDMEN1KMT2ANPSR1 | |
| SCHEMBL22219706 | 0.77 | HDAC4 (0.39) | SMN1; SMN2HDAC4 | |
| SCHEMBL22219705 | 0.77 | SMN1; SMN2 (0.33) | SMN1; SMN2HDAC4 | |
| SCHEMBL24328813 | 0.76 | MAPT (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL31395686 | 0.71 | TTR (0.47) | SMN1; SMN2HPGDMEN1KMT2ANPSR1 | |
| SCHEMBL30200421 | 0.71 | NPSR1 (0.41) | SMN1; SMN2HPGDMEN1KMT2ANPSR1 | |
| SCHEMBL15988843 | 0.71 | NPSR1 (0.41) | SMN1; SMN2HPGDMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12441703-B2 | Carboxamides as modulators of sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12441703-B2 | Carboxamides as modulators of sodium channels | TRPV1, SCN2A, SCN10A | SMN1; SMN2 349/4885HPGD 1512/4885MEN1 3203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.