Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.58 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.58 |
| ▸ | DHODH | Q02127 | 1/20 | 0.58 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 11/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316913 | 0.87 | PARP1 (0.54) | PARP1PARP2DHODHPKN1PKN2 | |
| SCHEMBL316463 | 0.87 | PARP1 (0.52) | PARP1PARP2DHODHLMNANPC1 | |
| SCHEMBL316533 | 0.82 | PARP1 (0.52) | PARP1DHODHLMNANPC1RAB9A | |
| SCHEMBL315601 | 0.78 | PARP1 (0.58) | PARP1CYP1A2CYP3A4CYP2C19NPC1 | |
| SCHEMBL30875610 | 0.74 | PARP1 (0.65) | PARP1PARP2DHODH | |
| SCHEMBL2265770 | 0.74 | PARP1 (0.65) | PARP1PARP2DHODH | |
| SCHEMBL3781416 | 0.73 | PARP1 (0.58) | PARP1PARP2DHODHPKN1PKN2 | |
| SCHEMBL4547990 | 0.73 | ATR (0.51) | CYP1A2CYP3A4CYP2C19NPC1RAB9A | |
| SCHEMBL29933473 | 0.72 | PARP1 (0.76) | PARP1PARP2DHODHPKN1PKN2 | |
| SCHEMBL29202872 | 0.72 | RAB9A (0.48) | MKNK1MKNK2NPC1RAB9ACYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093396-B2 | Benzthiazole inhibitors of poly(ADP-ribose)polymerase | ABBOTT LABORATORIES (US) | 2012-01-10 | — | — | US | claimed |
| US-20100183743-A1 | BENZTHIAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2010-07-22 | — | — | US | claimed |
| WO-2010083199-A1 | BENZTHIAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2010-07-22 | — | — | WO | claimed |
| US-8093396-B2 | Benzthiazole inhibitors of poly(ADP-ribose)polymerase | ABBOTT LABORATORIES (US) | 2012-01-10 | — | — | US | disclosed |
| US-20100183743-A1 | BENZTHIAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2010-07-22 | — | — | US | disclosed |
| WO-2010083199-A1 | BENZTHIAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100183743-A1 | BENZTHIAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | PARP1, PARP2, PARP6 | PARP1 1/4885PARP2 2/4885DHODH 567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.