Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27096890 | 0.90 | ALDH1A1 (0.50) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL3640391 | 0.88 | ALDH1A1 (0.58) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL27308580 | 0.86 | ADORA1 (0.53) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL3681896 | 0.86 | ALDH1A1 (0.56) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL2181231 | 0.85 | ALDH1A1 (0.54) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL21247108 | 0.81 | ALDH1A1 (0.50) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL21247154 | 0.81 | ALDH1A1 (0.50) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL21247109 | 0.81 | ALDH1A1 (0.50) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL21247316 | 0.80 | ALDH1A1 (0.57) | ALDH1A1HSD17B10MEN1KMT2AMAPT | |
| SCHEMBL21247166 | 0.78 | ALDH1A1 (0.55) | ALDH1A1HSD17B10MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100010017-A1 | CERTAIN THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-14 | — | — | US | disclosed |
| US-20100010017-A1 | CERTAIN THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-14 | — | — | US | disclosed |
| US-20100010017-A1 | CERTAIN THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-14 | — | — | US | disclosed |
| US-7576080-B2 | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |
| US-7576080-B2 | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |
| US-7576080-B2 | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |
| US-20070259896-A1 | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors | MEMORY PHARMACEUTICALS CORPORATION | 2007-11-08 | — | — | US | disclosed |
| US-20070259896-A1 | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors | MEMORY PHARMACEUTICALS CORPORATION | 2007-11-08 | — | — | US | disclosed |
| US-20070259896-A1 | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors | MEMORY PHARMACEUTICALS CORPORATION | 2007-11-08 | — | — | US | disclosed |
| EP-1831229-A1 | THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006071988-A1 | THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | MEMORY PHARMACEUTICALS CORP. (US) | 2006-07-06 | — | — | WO | disclosed |
| WO-2006071988-A1 | THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | MEMORY PHARMACEUTICALS CORP. (US) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010017-A1 | CERTAIN THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | PDE12, PDE4A, PDE7A | ALDH1A1 357/4885HSD17B10 268/4885MEN1 4246/4885 |
| US-20070259896-A1 | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors | PDE12, PDE7A, PDE7B | ALDH1A1 576/4885HSD17B10 237/4885MEN1 4155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.