Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705421 | 1.00 | HTR2C (0.34) | HTR2CULK1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL31706651 | 0.78 | CDC7 (0.53) | PIK3CDPIK3CANPC1ALDH1A1MAPT | |
| SCHEMBL30908171 | 0.78 | CDC7 (0.53) | PIK3CDPIK3CANPC1ALDH1A1MAPT | |
| SCHEMBL24130704 | 0.73 | SNCA (0.35) | PIK3CDPIK3CAPIK3CBPIK3CGDYRK1A | |
| Lithium Ion SCHEMBL31706711 | 0.73 | NAMPT (0.40) | HTR2CALDH1A1MAPTSMN1; SMN2 | |
| Lithium Ion SCHEMBL31705492 | 0.73 | NAMPT (0.40) | HTR2CALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL25399948 | 0.72 | DYRK1A (0.34) | ULK1PIK3CDPIK3CAPIK3CBPIK3CG | |
| Lithium Ion SCHEMBL31706112 | 0.72 | PLA2G10 (0.34) | HTR2CULK1PIK3CDPIK3CANPC1 | |
| Lithium Ion SCHEMBL31704985 | 0.72 | PLA2G10 (0.34) | HTR2CULK1PIK3CDPIK3CANPC1 | |
| Lithium Ion SCHEMBL31705522 | 0.68 | PIK3CD (0.37) | PIK3CDPIK3CAPIK3CBPIK3CGCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |