Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 17/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705492 | 1.00 | NAMPT (0.40) | NAMPTUSP2ALDH1A1ALOX15HTR2C | |
| SCHEMBL31705626 | 0.88 | NAMPT (0.41) | NAMPTUSP2ALDH1A1ALOX15KDM4E | |
| SCHEMBL31706494 | 0.84 | NAMPT (0.41) | NAMPT | |
| SCHEMBL31706303 | 0.84 | NAMPT (0.41) | NAMPT | |
| Lithium Ion SCHEMBL31705930 | 0.80 | NAMPT (0.36) | NAMPTUSP2ALDH1A1ALOX15HTR2C | |
| Lithium Ion SCHEMBL31705457 | 0.79 | NAMPT (0.41) | NAMPTUSP2ALDH1A1ALOX15KDM4E | |
| Lithium Ion SCHEMBL31705481 | 0.79 | NAMPT (0.41) | NAMPTUSP2ALDH1A1ALOX15KDM4E | |
| Lithium Ion SCHEMBL31704541 | 0.76 | NAMPT (0.39) | NAMPTUSP2ALDH1A1ALOX15HTR2C | |
| Lithium Ion SCHEMBL31705421 | 0.73 | HTR2C (0.34) | ALDH1A1HTR2CMAPTSMN1; SMN2 | |
| Lithium Ion SCHEMBL31705920 | 0.73 | HTR2C (0.34) | ALDH1A1HTR2CMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |